THE BEST SIDE OF THAPSIGARGIN

The results are expressed as relative fluorescence units (RFU) and presented as necessarily mean values ± common deviation for replicate measurements. Measurements was performed by a Luminex MAGPIX instrument plus a multiplex kit from Biorad. The measurements of chosen cytokines (IL1β and TNF) were being repeated in 4 independent experiments

In contrast, TAZ4SA was adequate, even on these kinds of compliant matrices, to promote traction force generation. Collectively our final results demonstrate a central function for TAZ activation in driving proliferative, contractile, and profibrotic signaling courses in fibroblasts independent of matrix stiffness, but a prerequisite for the stiffe